Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer.

ABSTRACT:

Background

Data are limited regarding the use of poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitors, such as veliparib, in combination with chemotherapy followed by maintenance as initial treatment in patients with high-grade serous ovarian carcinoma.

Methods

In an international, phase 3, placebo-controlled trial, we assessed the efficacy of veliparib added to first-line induction chemotherapy with carboplatin and paclitaxel and continued as maintenance monotherapy in patients with previously untreated stage III or IV high-grade serous ovarian carcinoma. Patients were randomly assigned in a 1:1:1 ratio to receive chemotherapy plus placebo followed by placebo maintenance (control), chemotherapy plus veliparib followed by placebo maintenance (veliparib combination

SUBMITTER: Coleman RL 

PROVIDER: S-EPMC6941439 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature