Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats.

ABSTRACT:

Background

Development of preclinical methodology for evaluating the abuse liability of electronic cigarettes (ECs) in adolescents is urgently needed to inform FDA regulation of these products. We previously reported reduced aversive effects of EC liquids containing nicotine and a range of non-nicotine constituents (e.g., propylene glycol, minor tobacco alkaloids) compared to nicotine alone in adult rats as measured using intracranial self-stimulation. The goal of this study was to compare the aversive effects of nicotine alone and EC aerosol extracts in adolescent rats as measured using conditioned taste aversion (CTA), which can be conducted during the brief adolescent period.

Methods and results

In Experiment 1, nicotine alone (1.0 or 1.5 mg/kg, s.c.) produced significant

SUBMITTER: Harris AC 

PROVIDER: S-EPMC6941564 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature