Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China.

ABSTRACT:

Background

Oral Epstein-Barr virus (EBV) status reflects host EBV activity and potentially links to EBV-associated diseases, however, factors influencing oral EBV loads or reactivation, such as environmental exposures or host factors, are not fully understood.

Methods

A 2-stage, multicenter, cross-sectional study of 6558 subjects from 21 administrative cities of southern China and 3 populations from representative geographical areas in China (referred to as the south, north, and northeastern populations) was performed. The relationships between demographical factors and environmental exposures to EBV loads were analyzed by logistic regression models.

Results

Current smoking, with a dose-response effect, was found to be strongly associated with higher oral EBV loads in

SUBMITTER: He YQ 

PROVIDER: S-EPMC6941616 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature