Joint evaluation of serum C-Reactive Protein levels and polygenic risk scores as risk factors for schizophrenia.

ABSTRACT: Several studies have indicated infectious and immune-related abnormalities in schizophrenia (Scz), including elevated serum C-reactive protein (CRP) - a well-known proxy for infections/immune abnormalities. A portion of the genetic risk for Scz can be estimated using the polygenic risk score (PGRS). It is not known whether there is an interaction in the risks traceable to CRP and PGRS. Patients with Scz and individuals without psychosis were evaluated systematically using DSM IV criteria (N=794, N=446, respectively). To estimate risk for Scz attributable to CRP and PGRS, serum from these participants was assayed for CRP levels using enzyme linked immunosorbent assays. PGRS was estimated from common DNA polymorphisms associated with Scz from genome wide association studies. CRP level and PG

SUBMITTER: Nimgaonkar VL 

PROVIDER: S-EPMC6941903 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature