Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youths on the Psychosis Spectrum.

ABSTRACT:

Background

Psychosis onset typically occurs in adolescence, and subclinical psychotic experiences peak in adolescence. Adolescence is also a time of critical neural and cognitive maturation. Using cross-sectional data from the Philadelphia Neurodevelopmental Cohort, we examined whether regional white matter (WM) development is disrupted in youths with psychosis spectrum (PS) features and whether WM maturation mediates the relationship between age and cognition in typically developing (TD) youths and youths with PS features.

Methods

We examined WM microstructure, as assessed via diffusion tensor imaging, in 670 individuals (age 10-22 years; 499 TD group, 171 PS group) by using tract-based spatial statistics. Multiple regressions were used to evaluate age × group interactions

SUBMITTER: Hegarty CE 

PROVIDER: S-EPMC6941904 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature