DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Exercise is widely recognised for its health enhancing benefits. Despite this, an overproduction of reactive oxygen and nitrogen species (RONS), outstripping antioxidant defence mechanisms, can lead to a state of (chronic) oxidative stress. DNA is a vulnerable target of RONS attack and, if left unrepaired, DNA damage may cause genetic instability.

Objective

This meta-analysis aimed to systematically investigate and assess the overall effect of studies reporting DNA damage following acute aerobic exercise.

Methods

Web of Science, PubMed, MEDLINE, EMBASE, and Scopus were searched until April 2019. Outcomes included (1) multiple time-points (TPs) of measuring DNA damage post-exercise, (2) two different quantification methods (comet assay and 8-oxo-2'-deoxyguan

SUBMITTER: Tryfidou DV 

PROVIDER: S-EPMC6942015 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature