Sexual dimorphism in gastric cancer: tumor-associated neutrophils predict patient outcome only for women.

ABSTRACT:

Purpose

Tumor-associated neutrophils (TANs) are part of the tumor immune microenvironment (TIME) and may contribute to gastric cancer (GC) biology. We hypothesized that TAN are enriched in the TIME, show sex-specific differences, and correlate with patient outcome.

Methods

We analyzed the distribution and putative tumor biological significance of TANs in a well-characterized, therapy-naïve, European GC cohort using immunohistochemical staining of myeloperoxidase (MPO), and digital image analysis using Definiens Tissue Studio^®.

Results

Different tumor compartments were examined, and TAN densities were correlated with various clinicopathological patient characteristics. TAN density showed a large interindividual variability ranging from 0 to 6711.0 TANs/mm

SUBMITTER: Clausen F 

PROVIDER: S-EPMC6942031 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature