Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.

ABSTRACT: Angiopoietin-like protein 2 (ANGPTL2) is a secreted glycoprotein homologous to angiopoietins. Previous studies suggest that tumor cell-derived ANGPTL2 has tumor-promoting function. Here, we conducted mechanistic analysis comparing ANGPTL2 function in cancer progression in a murine syngeneic model of melanoma and a mouse model of translocation renal cell carcinoma (tRCC). ANGPTL2 deficiency in tumor cells slowed tRCC progression, supporting a tumor-promoting role. However, systemic ablation of ANGPTL2 accelerated tRCC progression, supporting a tumor-suppressing role. The syngeneic model also demonstrated a tumor-suppressing role of ANGPTL2 in host tumor microenvironmental cells. Furthermore, the syngeneic model showed that PDGFRα⁺ fibroblasts in the tumor microenvironment express

SUBMITTER: Horiguchi H 

PROVIDER: S-EPMC6942048 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature