Incidence and causes of mildly to moderately elevated aminotransferase in Japanese patients with type 2 diabetes.

ABSTRACT:

Objectives

To identify the association of type 2 diabetes (T2DM) and liver disease with elevated ALT and factors associated with increased ALT in patients with and without T2DM.

Design and setting

We performed a retrospective study in adults with ≥ 2 claims for blood tests recorded in the Medical Data Vision claims database between 2010 and 2016.

Participants

Patients were entered into T2DM and non-DM groups based on diagnosis and medication claim codes.

Primary outcome measure

The primary endpoint was the first follow-up ALT elevation over three times the normal value, and etiologies were categorized by subsequent diagnoses. We estimated the ALT elevation incidence and association with T2DM using Poisson regression and Cox proportional hazard models.

Result

SUBMITTER: Chang CH 

PROVIDER: S-EPMC6942058 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature