Functional Modules of the Proteostasis Network.
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ABSTRACT:
SUBMITTER: Jayaraj GG
PROVIDER: S-EPMC6942124 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Functional Modules of the Proteostasis Network.
Jayaraj Gopal G GG Hipp Mark S MS Hartl F Ulrich FU
Cold Spring Harbor perspectives in biology 20200102 1
Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis) and prevent the accumulation of potentially toxic protein aggregates. This proteostasis network (PN) comprises the machineries for the biogenesis, folding, conformational maintenance, and degradation of proteins with molecular chaperones as central coordinators. Here, we review recent progress in understanding the modular architecture of the PN in mammalian cells and how it is modified during cell diff ...[more]
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