Cytosolic Ca2+ Buffers Are Inherently Ca2+ Signal Modulators.

ABSTRACT: For precisely regulating intracellular Ca2+ signals in a time- and space-dependent manner, cells make use of various components of the "Ca2+ signaling toolkit," including Ca2+ entry and Ca2+ extrusion systems. A class of cytosolic Ca2+-binding proteins termed Ca2+ buffers serves as modulators of such, mostly short-lived Ca2+ signals. Prototypical Ca2+ buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin. Although initially considered to function as pure Ca2+ buffers, that is, as intracellular Ca2+ signal modulators controlling the shape (amplitude, decay, spread) of Ca2+ signals, evidence has accumulated that calbindin-D28k and calretinin have additional Ca2+ sensor functions. These other functions are brought about by direct interactions with targ

SUBMITTER: Schwaller B 

PROVIDER: S-EPMC6942125 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature