Circulating Neprilysin in Patients With Heart Failure and Preserved Ejection Fraction.

ABSTRACT:

Background

In heart failure with reduced ejection fraction (HFrEF), elevated soluble neprilysin (sNEP) levels are associated with an increased risk of cardiovascular death, and its inhibition with sacubitril/valsartan has improved survival.

Objectives

This study sought to determine the relevance of sNEP as a biomarker in heart failure with preserved ejection fraction (HFpEF) and to compare circulating sNEP levels in patients with HFpEF with normal controls.

Methods

A case-control study was performed in 242 symptomatic patients with HFpEF previously enrolled in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction (RELAX) and Nitrates's Effect on Activity Tolerance in Heart Failure With Pre

SUBMITTER: Lyle MA 

PROVIDER: S-EPMC6942207 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature