Metatranscriptomics yields new genomic resources and sensitive detection of infections for diverse blood parasites.

ABSTRACT: Metatranscriptomics is a powerful method for studying the composition and function of complex microbial communities. The application of metatranscriptomics to multispecies parasite infections is of particular interest, as research on parasite evolution and diversification has been hampered by technical challenges to genome-scale DNA sequencing. In particular, blood parasites of vertebrates are abundant and diverse although they often occur at low infection intensities and exist as multispecies infections, rendering the isolation of genomic sequence data challenging. Here, we use birds and their diverse haemosporidian parasites to illustrate the potential for metatranscriptome sequencing to generate large quantities of genome-wide sequence data from multiple blood parasite species simultane

SUBMITTER: Galen SC 

PROVIDER: S-EPMC6942209 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature