Biomarkers that differentiate false positive urinalyses from true urinary tract infection.

ABSTRACT:

Background

The specificity of the leukocyte esterase test (87%) is suboptimal. The objective of this study was to identify more specific screening tests that could reduce the number of children who unnecessarily receive antimicrobials to treat a presumed urinary tract infection (UTI).

Methods

Prospective cross-sectional study to compare inflammatory proteins in blood and urine samples collected at the time of a presumptive diagnosis of UTI. We also evaluated serum RNA expression in a subset.

Results

We enrolled 200 children; of these, 89 were later demonstrated not to have a UTI based on the results of the urine culture obtained. Urinary proteins that best discriminated between children with UTI and no UTI were involved in T cell response proliferation (IL-9, IL-2), c

SUBMITTER: Shaikh N 

PROVIDER: S-EPMC6942213 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature