SIVcpz cross-species transmission and viral evolution toward HIV-1 in a humanized mouse model.

ABSTRACT: HIV-1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the human host. We followed the evolution of SIVcpz in humanized mice to mimic cross-species transmission. Increasing viral loads, CD4⁺ T-cell decline, and non-synonymous mutations were seen in the entire genome reflecting viral adaptation.

SUBMITTER: Curlin J 

PROVIDER: S-EPMC6942238 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature