Development and validation of a screening tool for early identification of bloodstream infection in older patients - a retrospective case-control study.

ABSTRACT: BACKGROUND:Delayed diagnosis of bloodstream infection (BSI) occurs in > 20% of older patients, with misdiagnosis in 35%. Our objective was to develop and validate a clinically useful screening tool to identify older patients with a high probability of having a BSI. METHODS:Hospitalized patients > 80 years old with BSI (n = 105/group) were evaluated for the tool development in this retrospective matched case-controlled study (learn cohort). The tool was validated in different retrospectively matched case and control patients > 80 years old (n = 120/group) and 65 to 79 years old (n = 250/group) (test cohort). Binary logistic regression was used to develop a screening tool using laboratory and clinical parameters that were significantly associated with BSI (P < 0.05; adjusted odds ratio (OR) 

SUBMITTER: Walker SAN 

PROVIDER: S-EPMC6942330 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature