Serious adverse drug reactions at two children's hospitals in South Africa.

ABSTRACT:

Background

The high HIV prevalence in South Africa may potentially be shaping the local adverse drug reaction (ADR) burden. We aimed to describe the prevalence and characteristics of serious ADRs at admission, and during admission, to two South African children's hospitals.

Methods

We reviewed the folders of children admitted over sequential 30-day periods in 2015 to the medical wards and intensive care units of each hospital. We identified potential ADRs using a trigger tool developed for this study. A multidisciplinary team assessed ADR causality, type, seriousness, and preventability through consensus discussion. We used multivariate logistic regression to explore associations with serious ADRs.

Results

Among 1050 patients (median age 11 months, 56% male, 2.8% HIV-

SUBMITTER: Mouton JP 

PROVIDER: S-EPMC6942333 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature