Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk.

ABSTRACT:

Background

Chronological age is a prominent risk factor for many types of cancers including colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even within the same age group, which may reflect heterogeneity in biological tissue aging between people. Epigenetic clocks based on DNA methylation are a useful measure of the biological aging process with the potential to serve as a biomarker of an individual's susceptibility to age-related diseases such as CRC.

Methods

We conducted a genome-wide DNA methylation study on samples of normal colon mucosa (N = 334). Subjects were assigned to three cancer risk groups (low, medium, and high) based on their personal adenoma or cancer history. Using previously established epigenetic clocks (Hannum, Horv

SUBMITTER: Wang T 

PROVIDER: S-EPMC6942339 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature