Genome-wide analysis of aberrant methylation of enhancer DNA in human osteoarthritis.

ABSTRACT:

Background

Osteoarthritis is a chronic musculoskeletal disease characterized by age-related gradual thinning and a high risk in females. Recent studies have shown that DNA methylation plays important roles in osteoarthritis. However, the genome-wide pattern of methylation in enhancers in osteoarthritis remains unclear.

Methods

To explore the function of enhancers in osteoarthritis, we quantified CpG methylation in human enhancers based on a public dataset that included methylation profiles of 470,870 CpG probes in 108 samples from patients with hip and knee osteoarthritis and hip tissues from healthy individuals. Combining various bioinformatics analysis tools, we systematically analyzed aberrant DNA methylation of the enhancers throughout the genome in knee osteoarthritis a

SUBMITTER: Lin X 

PROVIDER: S-EPMC6942377 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature