Clinical significance of focal ß-amyloid deposition measured by ¹⁸F-flutemetamol PET.

ABSTRACT:

Background

Although amyloid PET of typical Alzheimer's disease (AD) shows diffuse ß-amyloid (Aß) deposition, some patients show focal deposition. The clinical significance of this focal Aß is not well understood. We examined the clinical significance of focal Aß deposition in terms of cognition as well as Aß and tau cerebrospinal fluid (CSF) levels. We further evaluated the order of Aß accumulation by visual assessment.

Methods

We included 310 subjects (125 cognitively unimpaired, 125 mild cognitive impairment, and 60 AD dementia) from 9 referral centers. All patients underwent neuropsychological tests and ¹⁸F-flutemetamol (FMM) PET. Seventy-seven patients underwent CSF analysis. Each FMM scan was visually assessed in 10 regions (frontal, precuneus and posterior c

SUBMITTER: Kim SE 

PROVIDER: S-EPMC6942396 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature