Prostaglandin E₂ receptor EP4 regulates cell migration through Orai1.

ABSTRACT: The EP4 prostanoid receptors are one of four receptor subtypes for prostaglandin E₂ (PGE₂ ). Therefore, EP4 may play an important role in cancer progression. However, little information is available regarding their function per se, including migration and the cellular signaling pathway of EP4 in oral cancer. First, we found that mRNA and protein expression of EP4 was abundantly expressed in human-derived tongue squamous cell carcinoma cell lines HSC-3 and OSC-19. The EP4 agonist (ONO-AE1-437) significantly promoted cell migration in HSC-3 cells. In contrast, knockdown of EP4 reduced cell migration. Furthermore, we confirmed that knockdown of EP4 suppressed metastasis of oral cancer cells in the lungs of mice in vivo. Therefore, we focused on the mechanism of migration

SUBMITTER: Osawa K 

PROVIDER: S-EPMC6942437 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature