Diagnostic accuracy of fetal MRI to detect cleft palate: a meta-analysis.

ABSTRACT: This systematic review aims to determine the diagnostic accuracy of fetal MRI for detecting cleft palate in fetuses at risk for orofacial clefts. Pubmed, Embase, and CINAHL were searched systematically. A diagnostic study was included if it performed MRI (index test) and postnatal examination (reference test) in fetuses at risk for orofacial clefts. Methodological quality was assessed using the QUADAS-2. A meta-analysis was performed with a random-effects model, calculating the pooled sensitivity, specificity, and area under the curve. The search resulted in eight studies (334 fetuses) to be included: four prospective and four retrospective studies. The applicability concern was low. There was, however, a risk of selection and information bias. All studies showed that MRI well predicted th

SUBMITTER: van der Hoek-Snieders HEM 

PROVIDER: S-EPMC6942582 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature