Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model.

ABSTRACT:

Purpose

Small-molecule inhibitors have revolutionized treatment of certain genomically defined solid cancers. Despite breakthroughs in treating systemic disease, central nervous system (CNS) metastatic progression is common, and advancements in treating CNS malignancies remain sparse. By improving drug penetration across a variably permeable blood-brain barrier and diffusion across intratumoral compartments, more uniform delivery and distribution can be achieved to enhance efficacy.

Experimental design

Ultrasmall fluorescent core-shell silica nanoparticles, Cornell prime dots (C' dots), were functionalized with α_v integrin-binding (cRGD), or nontargeting (cRAD) peptides, and PET labels (¹²⁴I, ⁸⁹Zr) to investigate the utility of dual-modality

SUBMITTER: Juthani R 

PROVIDER: S-EPMC6942644 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature