Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer.

ABSTRACT:

Background

It remains controversial if radical prostatectomy or definitive radiation therapy produces equivalent outcomes in high-risk localized prostate cancer.

Methods

We queried The Surveillance, Epidemiology, and End Results (SEER) database for those who received upfront surgery or who were recommended for surgery but instead received radiation. Inverse probability of treatment weighing was used to adjust for covariate imbalance and the weighted Cox proportional hazards model was used to estimate the effects of treatment groups on survival. A meta-analysis was performed to pool estimates from published studies.

Results

Among eligible 62 533 patients, 59 540 had upfront surgery and 2993 patients had upfront radiotherapy. EBRT + BT was associated with a superior can

SUBMITTER: Yin M 

PROVIDER: S-EPMC6943084 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature