CD44-associated radioresistance of glioblastoma in irradiated brain areas with optimal tumor coverage.

ABSTRACT: Glioblastoma multiforme (GBM) requires radiotherapy (RT) as its definitive management. However, GBM still has a high local recurrence rate even after RT. Cancer stem-like cells (CSCs) might enable GBM to evade irradiation damage and cause therapeutic failure. The optimal RT plan should achieve a planning target volume (PTV) coverage of more than 95% but cannot always meet the requirements. Here, we demonstrate that irradiation with different tumor coverage rates to different brain areas has similar effects on GBM. To retrospectively analyze the relationship between PTV coverage and the survival rate in 26 malignant glioblastoma patients, we established primary cell lines from patient-derived malignant glioblastoma cells with the PTV₉₅ (PTV coverage of more than 95%) program (GBM

SUBMITTER: Liu WH 

PROVIDER: S-EPMC6943151 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature