YAP1 promotes multidrug resistance of small cell lung cancer by CD74-related signaling pathways.

ABSTRACT:

Background

Our previous research found that YAP1 may have a role in multidrug resistance (MDR) in small cell lung cancer (SCLC). However, its underlying mechanism is unknown.

Methods

In this study, we investigated the expression of YAP1 using immunohistochemical staining and assessed the relationship between the expression of YAP1 and overall survival in patients with SCLC. We established H69 stable cell lines that overexpressed constitutively active YAP1 and H446 stable cell lines that dominate negative YAP1. We conducted CCK-8, flow cytometric analysis, and in vivo chemosensitivity experiments to evaluate the function of YAP1 in drug sensitivity apoptosis in vitro and in vivo.

Results

The results indicated that patients with high YAP1 expression have shorter surviva

SUBMITTER: Song Y 

PROVIDER: S-EPMC6943160 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature