Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4⁺ Treg Cells in Patients with Rheumatoid Arthritis.

ABSTRACT:

Background/aims

Rheumatoid arthritis (RA) is a progressive, chronic, even disabling systemic autoimmune disease. Imbalance between pathogenic immune cells and immunosuppressive cells is associated with the pathogenesis and development of RA and other autoimmune diseases. As Foxp3 is also expressed on activated CD4⁺ cells in the presence of inflammation, the identification of Treg cells in patients with RA remains a challenge.

Methods

Comprehensive analyses were carried out by Flow cytometry. Expression of Helios, CD226, T cell immunoreceptor with Ig and ITIM domains clinical samples and healthy controls.

Results

We have systemically examined three potential markers, Helios, CD226 and TIGIT, that are possibly related to Treg identification, and found that He

SUBMITTER: Yang M 

PROVIDER: S-EPMC6943339 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature