Effects of irisin on the differentiation and browning of human visceral white adipocytes.

ABSTRACT: BACKGROUND:The aim of this study was to explore the effects of irisin on human visceral adipose tissue and adipocytes functions. METHODS:Fresh human visceral white adipose tissues derived from 11 donors were used to examine the effects of irisin on browning, adipogenesis and osteogenesis gene expression, and anti-inflammatory properties. Preadipocytes were also used to examine the effects of irisin on mitochondrial respiration, adipogenic differentiation, and osteogenic differentiation. KEY RESULTS:Irisin significantly increased cellular mitochondrial energy metabolism in differentiated visceral adipocytes. Irisin also increased mRNA levels of transcriptional regulators of brite/beige adipocytes (UCP-1, PGC1α, PRDM16, TMEM26, and CD137) in subcutaneous white adipose tissue but not in visce

SUBMITTER: Li H 

PROVIDER: S-EPMC6943454 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature