Visual deprivation modifies glutamate receptor expression in visual and auditory centers.

ABSTRACT: Changes in the electrical activities of visual and auditory thalamic-cortical regions account for the cross-modal enhancement of auditory perception following visual deprivation, but the molecular regulatory factors mediating these changes remain elusive. In this study, we showed that the expression patterns of five glutamate receptor (GluR) subunits which involved in regulating the synaptic plasticity in mouse primary visual (V1) cortex and primary auditory (A1) cortex undergone elaborate modification with layer-specificity after visual deprivation using dark-exposure (DE). The expression levels of NR1 and NR2B were increased, and those of GluR1 and NR2B in the V1 cortex were decreased after DE. In the A1 cortex, the expression levels of NR1, NR2A and NR2B were increased, and the expressi

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6943468 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature