1H-NMR metabolomics identifies significant changes in hypermetabolism after glutamine administration in burned rats.

ABSTRACT: Glutamine is an important amino acid that plays a crucial role in nutritional therapy for patients with burns, but its effects on post-burn metabolism and the underlying mechanisms are unclear. In this study, 1H nuclear magnetic resonance spectroscopy (1H-NMR) was used to examine the effects of glutamine on plasma metabolites in burned rats and to explore the underlying mechanisms. After burn injury, the rats exhibited significant increases in resting energy expenditure (REE) and hypercatabolism, and anabolism was inhibited. The levels of metabolites that reflect the proteolysis of skeletal muscle, such as alanine, histidine, leucine, valine, 3-methylhistidine and creatine, were significantly increased. In addition, the burned rats exhibited energy synthesis dysfunction, as evidenced by a

SUBMITTER: Yang G 

PROVIDER: S-EPMC6943476 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature