Antileishmanial Compounds Isolated from Psidium Guajava L. Using a Metabolomic Approach.

ABSTRACT: With an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available medical treatments involve side effects, including toxicity, non-specific targeting, and resistance development. Thus, new antileishmanial chemical entities are of the utmost interest to fight against this disease. The aim of this study was to obtain potential antileishmanial natural products from Psidium guajava leaves using a metabolomic workflow. Several crude extracts from P. guajava leaves harvested from different locations in the Lao People's Democratic Republic (Lao PDR) were profiled by liquid chromatography coupled to high-resolution mass spectrometry, and subsequently evaluated for their antileishmanial activities. The putative active compounds

SUBMITTER: Phakeovilay C 

PROVIDER: S-EPMC6943623 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature