The role of melatonin in polycystic ovary syndrome: A review.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder, affecting approximately 20% of women within reproductive age. It is associated with hyperandrogenism, obesity, menstrual irregularity, and anovulatory infertility. Melatonin is the main pineal gland hormone involved in the regulation of the circadian rhythm. In recent years, it has been observed that a reduction in melatonin levels of follicular fluid exists in PCOS patients. Melatonin receptors in the ovary and intra-follicular fluid adjust sex steroid secretion at different phases of ovarian follicular maturation. Moreover, melatonin is a strong antioxidant and an effective free radical scavenger, which protects ovarian follicles during follicular maturation.

Objective

In this paper, we conduct

SUBMITTER: Mojaverrostami S 

PROVIDER: S-EPMC6943797 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature