Cognitive function after surgery with regional or general anesthesia: A population-based study.

ABSTRACT: INTRODUCTION:Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). METHODS:Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition over time in participants exposed to RA or GA. RESULTS:When compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of -0.041, P = .011) and GA (-0.061, P < .001); these rates did not differ. In analysis of the domain-specific scores, an accelerated decline in memory was observed after GA (-0.065, P 

SUBMITTER: Sprung J 

PROVIDER: S-EPMC6943821 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature