Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study.

ABSTRACT:

Background

Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension.

Methods

We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Several genetic variants in HTR2A including rs7330636, rs9590999, rs2183057, and rs4942595 were selected and genotyped.

Results

In hypertensive participants in cohort A, the baseline systolic blood pressure and body mass index were 141.80 ± 17.20 mg/dL and 24.48 ± 4.75 kg/m², respectively, which were higher than in those without hypertension (p < 0.001). rs4942595TC genotype was associated with hypertension in cohort A (O

SUBMITTER: Choi JR 

PROVIDER: S-EPMC6943889 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature