Multi-level transcriptome sequencing identifies COL1A1 as a candidate marker in human heart failure progression.

ABSTRACT:

Background

Heart failure (HF) has been recognized as a global pandemic with a high rate of hospitalization, morbidity, and mortality. Although numerous advances have been made, its representative molecular signatures remain largely unknown, especially the role of genes in HF progression. The aim of the present prospective follow-up study was to reveal potential biomarkers associated with the progression of heart failure.

Methods

We generated multi-level transcriptomic data from a cohort of left ventricular heart tissue collected from 21 HF patients and 9 healthy donors. By using Masson staining to calculate the fibrosis percentage for each sample, we applied lasso regression model to identify the genes associated with fibrosis as well as progression. The genes were further v

SUBMITTER: Hua X 

PROVIDER: S-EPMC6943904 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature