Topographic mapping of left ventricular regional contractile injury in ischemic mitral regurgitation.

ABSTRACT:

Objective

Restrictive leaflet tethering resulting from regional left ventricular (LV) contractile injury causes ischemic mitral regurgitation (MR). We hypothesized that 3-dimensional LV topographic mapping by MRI-based multiparametric strain analysis could characterize the regional contractile injury patterns that differentiate ischemic coronary artery disease patients who have ischemic MR from those who do not.

Methods

Magnetic resonance imaging-based multiparametric strain data were calculated for 15,300 LV grid points in 100 normal volunteers. Strain parameters from ischemic MR (n = 10) and ischemic no-MR (n = 36) patients were then normalized to this normal human strain database with z score quantification of standard deviation from the normal mean. Mean multiparametric

SUBMITTER: Lancaster TS 

PROVIDER: S-EPMC6944062 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature