Identification of biological pathways and genes associated with neurogenic heterotopic ossification by text mining.

ABSTRACT:

Background

Neurogenic heterotopic ossification is a disorder of aberrant bone formation affecting one in five patients sustaining a spinal cord injury or traumatic brain injury (SCI-TBI-HO). However, the underlying mechanisms of SCI-TBI-HO have proven difficult to elucidate. The aim of the present study is to identify the most promising candidate genes and biological pathways for SCI-TBI-HO.

Methods

In this study, we used text mining to generate potential explanations for SCI-TBI-HO. Moreover, we employed several additional datasets, including gene expression profile data, drug data and tissue-specific gene expression data, to explore promising genes that associated with SCI-TBI-HO.

Results

We identified four SCI-TBI-HO-associated genes, including GDF15, LDLR, CCL2, a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6944123 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature