Presence of intraepithelial food antigen in patients with active eosinophilic oesophagitis.

ABSTRACT:

Background

Although eosinophilic oesophagitis (EoE) is putatively mediated by an abnormal response to food antigen, the oesophagus is considered relatively impermeable to large molecules.

Aim

To assess whether food antigens penetrate the oesophageal mucosa in patients with EoE.

Methods

Anti-gliadin staining was performed in three groups: active EoE, inactive EoE and EoE patients on a low or gluten free diet. To appraise the specificity of our results, we also performed gliadin staining on six patients without oesophageal disease who were consuming gluten. The groups with EoE on gluten also underwent endoscopic infusion with gluten containing soy sauce and repeat biopsies during the endoscopy. We measured eosinophil density, dilated intercellular spaces (on a 0-4+ scal

SUBMITTER: Marietta EV 

PROVIDER: S-EPMC6944330 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature