Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives.

ABSTRACT: Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a method for simulating relatives that can utilize either sex-specific or sex averaged genetic maps and also either a model of crossover interference or the traditional Poisson model for inter-crossover distances. To characterize the impact of previously ignored mechanisms, we simulated data for all four combinations of these factors. We found that modeling crossover interference decreases the standard deviation of pairwise IBD proportions by 10.4% on average in full siblings through second cousins. B

SUBMITTER: Caballero M 

PROVIDER: S-EPMC6944377 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature