Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing.

ABSTRACT: Hibernation is an established strategy used by some homeothermic organisms to survive cold environments. In true hibernation, the core body temperature of an animal may drop to below 0°C and metabolic activity almost cease. The phenomenon of hibernation in humans is receiving renewed interest since several cases of victims exhibiting core body temperatures as low as 13.7°C have been revived with minimal lasting deficits. In addition, local cooling during radiotherapy has resulted in normal tissue protection. The experiments described in this paper were prompted by the results of a very limited pilot study, which showed a suppressed DNA repair response of mouse lymphocytes collected from animals subjected to 7-Gy total body irradiation under hypothermic (13°C) conditions, compared to normot

SUBMITTER: Baird BJ 

PROVIDER: S-EPMC6944433 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature