Ontology highlight
ABSTRACT:
SUBMITTER: Courel M
PROVIDER: S-EPMC6944446 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
eLife 20191219
mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of broadly acting mRNA decay and repression factors, and with available CLIP and related data. This revealed the central role of GC content in mRNA fate, in terms of P-body localization, mRNA translation and mRNA stability: P-bodies contain mostly AU-rich mRNAs, which have ...[more]