Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans.

ABSTRACT:

Background

Inorganic nitrate, abundant in leafy green vegetables and beetroot, is thought to have protective health benefits. Adherence to a Mediterranean diet reduces the incidence and severity of coronary artery disease, whereas supplementation with nitrate can improve submaximal exercise performance. Once ingested, oral commensal bacteria may reduce nitrate to nitrite, which may subsequently be reduced to nitric oxide during conditions of hypoxia and in the presence of "nitrite reductases" such as heme- and molybdenum-containing enzymes.

Objective

We aimed to explore the putative effects of inorganic nitrate and nitrite on mitochondrial function in skeletal muscle.

Methods

Mice were subjected to a nitrate/nitrite-depleted diet for 2 wk, then supplemented with sodiu

SUBMITTER: Ntessalen M 

PROVIDER: S-EPMC6944528 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature