Soluble guanylate cyclase contribute genetic susceptibility to essential hypertension in the Han Chinese population.

ABSTRACT:

Background

Animal study found that soluble guanylate cyclase (sGC) plays an important role in development of hypertension (HT) by affecting the NO-sGC-CGMP signaling pathway. This study aims to evaluate the association of sGC with essential hypertension (EH) in the Han Chinese population.

Methods

This case-control study included 2,012 hypertensive cases and 2,210 controls, and 6 tagging single nucleotide polymorphisms (SNPs) were selected (rs3806777, rs3806782, rs3796576 and rs7698460 in GUCY1A3, as well as rs2229202 and rs1459853 in GUCY1B3). Then the association of the six SNPs with EH was further evaluated in this study.

Results

The results indicated that the A/A genotype of rs1459853 in GUCY1B3 was associated with higher HT risk, and the odds

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6944586 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature