Exploration of the relationships between tumor mutation burden with immune infiltrates in clear cell renal cell carcinoma.

ABSTRACT:

Background

Whether tumor mutation burden (TMB) correlated with improved survival outcomes or promotion of immunotherapies remained controversy in various malignancies. We aimed to investigate the prognosis of TMB and the potential association with immune infiltrates in clear cell renal cell carcinoma (ccRCC).

Methods

We downloaded the somatic mutation data of 336 ccRCC patients from the Cancer Genome Atlas (TCGA) database, and analyzed the mutation profiles with "maftools" package. TMB was calculated and we classified the samples into high-TMB and low-TMB group. Differential analysis was conducted to compare the expression profiles between two groups using "limma" package, and we identified the 9 hub TMB-related signature from batch survival analysis. Gene ontology (GO) anal

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6944593 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature