MicroRNAs Regulate Multiple Aspects of Locomotor Behavior in Drosophila.

ABSTRACT: Locomotion is an ancient and fundamental output of the nervous system required for animals to perform many other complex behaviors. Although the formation of motor circuits is known to be under developmental control of transcriptional mechanisms that define the fates and connectivity of the many neurons, glia and muscle constituents of these circuits, relatively little is known about the role of post-transcriptional regulation of locomotor behavior. MicroRNAs have emerged as a potentially rich source of modulators for neural development and function. In order to define the microRNAs required for normal locomotion in Drosophila melanogaster, we utilized a set of transgenic Gal4-dependent competitive inhibitors (microRNA sponges, or miR-SPs) to functionally assess ca. 140 high-confide

SUBMITTER: Donelson NC 

PROVIDER: S-EPMC6945011 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature