Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis.

ABSTRACT: Scleroderma, or systemic sclerosis (SSc), is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. The most common cause of death in people with SSc is lung disease, but the pathogenesis of lung disease in SSc is insufficiently understood to devise specific treatment strategies. Developing targeted treatments requires not only the identification of molecular processes involved in SSc-associated lung disease, but also understanding of how these processes interact to drive pathology. One potentially powerful approach is to identify alleles that interact genetically to influence lung outcomes in patients with SSc. Analysis of interactions, rather than individual allele effects, has the potential to delineate molecular interactions that are important in S

SUBMITTER: Tyler A 

PROVIDER: S-EPMC6945038 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature