Interleukin-18 and outcome after allogeneic stem cell transplantation: A retrospective cohort study.

ABSTRACT:

Background

Interleukin-18 (IL-18) is involved in endothelial activation and dysfunction, and in the pathogenesis and severity of acute graft-versus-host disease (aGVHD). Its relevance for patient outcome after allogeneic stem cell transplantation (alloSCT) has not yet been comprehensively addressed.

Methods

Pre-transplant serum levels of free IL-18 were retrospectively assessed in a cohort of 589 patients (training cohort). Results were validated in 688 patients allografted in a different centre. The primary endpoint was overall survival (OS). Secondary endpoints included incidences of non-relapse mortality (NRM), relapse, and aGVHD.

Findings

In the training cohort, higher pre-transplant levels of free IL-18 were significantly associated with worse OS (hazard ratio [H

SUBMITTER: Radujkovic A 

PROVIDER: S-EPMC6945194 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature