The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults.

ABSTRACT:

Background

Pathological processes contributing to Alzheimer's disease begin decades prior to the onset of clinical symptoms. There is significant variation in cognitive changes in the presence of pathology, functional connectivity may be a marker of compensation to amyloid; however, this is not well understood.

Methods

We recruited 64 cognitively normal older adults who underwent neuropsychological testing and biannual magnetic resonance imaging (MRI), amyloid imaging with Pittsburgh compound B (PiB)-PET, and glucose metabolism (FDG)-PET imaging for up to 6 years. Resting-state MRI was used to estimate connectivity of seven canonical neural networks using template-based rotation. Using voxel-wise paired t-tests, we identified neural networks that displayed significant change

SUBMITTER: Lin C 

PROVIDER: S-EPMC6945413 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature