Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors.

ABSTRACT:

Background

Dysregulation of alternative splicing (AS) is a critical signature of cancer. However, the regulatory mechanisms of cancer-specific AS events, especially the impact of DNA methylation, are poorly understood.

Methods

By using The Cancer Genome Atlas (TCGA) SpliceSeq and TCGA data for ten solid tumor types, association analysis was performed to characterize the potential link between cancer-specific AS and DNA methylation. Functional and pathway enrichment analyses were performed, and the protein-protein interaction (PPI) network was constructed with the String website. The prognostic analysis was carried out with multivariate Cox regressions models.

Results

15,818 AS events in 3955 annotated genes were identified across ten solid tumor types. The different D

SUBMITTER: Sun X 

PROVIDER: S-EPMC6945449 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature