Polysomnographic Endotyping to Select Patients with Obstructive Sleep Apnea for Oral Appliances.

ABSTRACT: Rationale: Oral appliance therapy is efficacious in many patients with obstructive sleep apnea (OSA), but prediction of treatment outcome is challenging. Small, detailed physiological studies have identified key OSA endotypic traits (pharyngeal collapsibility and loop gain) as determinants of greater oral appliance efficacy.Objectives: We used a clinically applicable method to estimate OSA traits from routine polysomnography and identify an endotype-based subgroup of patients expected to show superior efficacy.Methods: In 93 patients (baseline apnea-hypopnea index [AHI], ≥20 events/h), we examined whether polysomnography-estimated OSA traits (pharyngeal: collapsibility and muscle compensation; nonpharyngeal: loop gain, arousal threshold, and ventilatory response to aro

SUBMITTER: Bamagoos AA 

PROVIDER: S-EPMC6945467 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature